The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

N Rahmioglu, S Mortlock, M Ghiasi, PL Møller… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Shared molecular genetic mechanisms underlie endometriosis and migraine comorbidity

EO Adewuyi, Y Sapkota… - Genes, 2020 - mdpi.com
Observational epidemiological studies indicate that endometriosis and migraine co-occur
within individuals more than expected by chance. However, the aetiology and biological …

Genome-wide association study identifies a locus at 7p15. 2 associated with endometriosis

JN Painter, CA Anderson, DR Nyholt, S Macgregor… - Nature …, 2011 - nature.com
Endometriosis is a common gynecological disease associated with pelvic pain and
subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals …

Epidemiologic and genetic associations of endometriosis with depression, anxiety, and eating disorders

D Koller, GA Pathak, FR Wendt, DS Tylee… - JAMA network …, 2023 - jamanetwork.com
Importance Endometriosis is a common chronic gynecologic pathology with a large negative
impact on women's health. Beyond severe physical symptoms, endometriosis is also …

Genome-wide association study link novel loci to endometriosis

HM Albertsen, R Chettier, P Farrington, K Ward - PloS one, 2013 - journals.plos.org
Endometriosis is a common gynecological condition with complex etiology defined by the
presence of endometrial glands and stroma outside the womb. Endometriosis is a common …

Mechanisms of pain in endometriosis

M Morotti, K Vincent, CM Becker - … Journal of Obstetrics & Gynecology and …, 2017 - Elsevier
Pain is the central symptom in endometriosis and often persists despite treatment of the
disease. Multiple mechanisms underlie endometriosis-associated pain including …

Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities

IM McGrath, GW Montgomery… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Endometriosis remains a poorly understood disease, despite its high
prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of …

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Y Sapkota, V Steinthorsdottir, AP Morris… - Nature …, 2017 - nature.com
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …

Beyond endometriosis genome-wide association study: from genomics to phenomics to the patient

KT Zondervan, N Rahmioglu, AP Morris… - Seminars in …, 2016 - thieme-connect.com
Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the
causal pathogenic mechanism remains unknown. Genome-wide association studies …

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

N Rahmioglu, S Macgregor, AW Drong… - Human molecular …, 2015 - academic.oup.com
Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and
subfertility, and has been associated with decreased body mass index (BMI). Genetic …