The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …

Background. Advances in next-generation sequencing (NGS) technologies allow
comprehensive studies of genetic diversity over the entire genome of human …

Human cytomegalovirus is a widespread pathogen of major medical importance. It causes
significant morbidity and mortality in immunocompromised individuals, and congenital …

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural
infection although little is known about the limits or patterns of HCMV diversity among …

Most human cytomegalovirus (HCMV) genes are highly conserved in sequence among
strains, but some exhibit a substantial degree of variation. Two of these genes are UL146 …

The complete genome of human cytomegalovirus (HCMV) was elucidated almost 25 years
ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic …

We have assessed two approaches to sequencing complete human cytomegalovirus
(HCMV) genomes (236 kbp) in DNA extracted from infected cell cultures (strains 3157 …

Human cytomegalovirus (HCMV) strains display genetic polymorphisms, and these
polymorphisms can be analyzed to study viral transmission and pathogenesis. Recently …

Human cytomegalovirus (HCMV) contains a large and complex E-type genome. There are
both clinical isolates of the virus that have been passaged minimally in fibroblasts and so …

Background Although the sequence of the human cytomegalovirus (HCMV) genome is
generally conserved among unrelated clinical strains, some open reading frames (ORFs) …