Benzodiazepines in Alzheimer's disease: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …

Insights on benzodiazepines' potential in Alzheimer's disease

HM Al-Kuraishy, AI Al-Gareeb, AA Alsayegh… - Life Sciences, 2023 - Elsevier
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

The benzodiazepine–dementia disorders link: current state of knowledge

A Pariente, SB de Gage, N Moore, B Bégaud - CNS drugs, 2016 - Springer
The short-term effects of benzodiazepines on memory are well established and are
suspected in the long term. Eleven studies have been published so far concerning …

Benzodiazepines and related drugs as a risk factor in Alzheimer's disease dementia

M Ettcheto, J Olloquequi, E Sanchez-Lopez… - Frontiers in aging …, 2020 - frontiersin.org
Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice
due to their anxiolytic, hypnotic, and muscle relaxant properties. Yet, their chronic use is …

The GABAergic system in Alzheimer's disease: a systematic review with meta-analysis

G Carello-Collar, B Bellaver, PCL Ferreira… - Molecular …, 2023 - nature.com
The γ-aminobutyric acid (GABA) ergic system is the primary inhibitory neurotransmission
system in the mammalian brain. Its dysregulation has been shown in multiple brain …

Precision medicine of sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD)

CH Lin, HT Yang, PK Chen, SH Wang… - … Disease and Treatment, 2020 - Taylor & Francis
Objective Behavioral and psychological symptoms of dementia (BPSD) are associated with
poorer prognosis of dementia. A 24-week study demonstrated that sodium benzoate, a D …

GABA attenuates amyloid toxicity by downregulating its endocytosis and improves cognitive impairment

X Sun, X Meng, J Zhang, Y Li, L Wang… - Journal of …, 2012 - content.iospress.com
GABA (gamma-aminobutyric acid) receptor modulators have been investigated as a
potential treatment strategy in Alzheimer's disease (AD). In the present study, we found that …

Use of benzodiazepines in Alzheimer's disease: a systematic review of literature

M Defrancesco, J Marksteiner… - International Journal …, 2015 - academic.oup.com
Background: Benzodiazepines are frequently prescribed in patients with Alzheimer's
disease. Unfortunately, studies evaluating their benefits and risks in these patients are …

Treatment options in alzheimer s disease: the GABA story

M Solas, E Puerta, MJ Ramirez - Current pharmaceutical …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research
focused on identifying compounds that restore cognition and memory in AD patients is a …

Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia

MG Borda, A Jaramillo‐Jimenez… - … Journal of Geriatric …, 2021 - Wiley Online Library
Objectives We aim to study the effects of the prescription of benzodiazepines and
antidepressants on cognitive and functional decline in older adults living with Alzheimer's …