Topological small-world organization of the fibroblastic reticular cell network determines lymph node functionality

M Novkovic, L Onder, J Cupovic, J Abe, D Bomze… - PLoS …, 2016 - journals.plos.org
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and
establish distinct microenvironmental niches to provide key molecules that drive innate and …

Topological structure and robustness of the lymph node conduit system

M Novkovic, L Onder, G Bocharov, B Ludewig - Cell Reports, 2020 - cell.com
Fibroblastic reticular cells (FRCs) form a road-like cellular network in lymph nodes (LNs) that
provides essential chemotactic, survival, and regulatory signals for immune cells. While the …

Lymph node fibroblastic reticular cells steer immune responses

L Li, J Wu, R Abdi, CM Jewell, JS Bromberg - Trends in immunology, 2021 - cell.com
Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive
compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by …

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

K Knoblich, S Cruz Migoni, SM Siew, E Jinks… - PLoS …, 2018 - journals.plos.org
The microenvironment of lymphoid organs can aid healthy immune function through
provision of both structural and molecular support. In mice, fibroblastic reticular cells (FRCs) …

Differentiation and activation of fibroblastic reticular cells

M Lütge, NB Pikor, B Ludewig - Immunological Reviews, 2021 - Wiley Online Library
Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that
form dedicated microenvironmental niches to secure induction and regulation of innate and …

Protective fibroblastic niches in secondary lymphoid organs

A De Martin, Y Stanossek, NB Pikor… - Journal of Experimental …, 2024 - rupress.org
Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

VN Kapoor, S Müller, S Keerthivasan, M Brown… - Nature …, 2021 - nature.com
Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture
and regulate lymphocyte compartmentalization, homeostasis, and innate and adaptive …

Conserved stromal–immune cell circuits secure B cell homeostasis and function

M Lütge, A De Martin, C Gil-Cruz… - Nature …, 2023 - nature.com
B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral
immunity with B cell priming and memory maintenance being orchestrated across lymphoid …

Network approaches for dissecting the immune system

H Shi, KK Yan, L Ding, C Qian, H Chi, J Yu - Iscience, 2020 - cell.com
The immune system is a complex biological network composed of hierarchically organized
genes, proteins, and cellular components that combat external pathogens and monitor the …

Visualization and functional characterization of lymphoid organ fibroblasts

L Onder, HW Cheng, B Ludewig - Immunological Reviews, 2022 - Wiley Online Library
Fibroblastic reticular cells (FRCs) are specialized stromal cells of lymphoid organs that
generate the structural foundation of the tissue and actively interact with immune cells …