The genomic revolution in the past decade fuelled by breathtaking advances in sequencing
technologies has defined several new genetic diseases of the immune system. Many of …

Primary immunodeficiency is a group of disorders associated with susceptibility to infectious
agents and the development of various comorbidities. Many primary immunodeficiencies are …

This manuscript reviews selected topics in primary immunodeficiency diseases (PIDDs)
published in 2017. These include (1) the role of follicular T cells in the differentiation of B …

Over the past 20 years, the rapid evolution in the diagnosis and treatment of primary
immunodeficiencies (PI) and the recognition of immune dysregulation as a feature in some …

A broad spectrum of autoimmunity is now well described in patients with primary
immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID …

Immunoglobulin (Ig) therapy is the mainstay for treatment in the majority of primary immune
deficiencies. While B cell defects are the predominant conditions in man, other diseases in …

Primary immunodeficiency diseases (PID) result from defects in genes affecting the immune
and other systems in many and varied ways (,). Until the last few years, treatments have …

A general review of advances in the treatment of Primary Immunodeficiencies (PID) has
been performed. Treatment with immunoglobulins is indicated in cases of humoral …

Around the world, over 6 million people are affected by primary immunodeficiencies, among
which 70 to 90% remain undiagnosed (1). More than 430 different primary …

Although primary immunodeficiency disorders are relatively rare, intensive investigation of
these disorders has yielded a great wealth of understanding of basic immunologic …