Drug repositioning continues to be the most effective, practicable possibility to treat COVID-
19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus …

The S-glycoprotein (Spike) of the SARS-CoV-2 forms a complex with the human
transmembrane protein angiotensin-converting enzyme 2 (ACE2) during infection. It forms …

After over two years of living with Covid-19 and hundreds of million cases worldwide there is
still an unmet need to find proper treatments for the novel coronavirus, due also to the rapid …

Background: SARS-CoV-2 has been shown to bind the host cell ACE2 receptor through its
spike protein receptor binding domain (RBD), required for its entry into the host cells …

The interaction between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2
(ACE2) is essential to viral attachment and the subsequent fusion process. Interfering with …

COVID-19 is a persistent public health concern due to the emergence of more virulent and
contagious variants resulting from mutations in the spike protein. The spike protein in newer …

The emergence of SARS-CoV-2-Spike mutants not only enhances viral infectivity but also
lead to treatment failure. Gaining a comprehensive understanding of the molecular binding …

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) continues to spread globally, and rapid viral evolution and the emergence of …

For the last two years, the COVID-19 pandemic has continued to bring consternation on
most of the world. According to recent WHO estimates, there have been more than 5.6 …

Methods Using the crystal structure of SARS-CoV-2 Spike complexed with ACE2 (PDB ID:
6VW1) as a template, we developed a pharmacophore model of functional centers of the …