Abstract Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and
potent pro-inflammatory activities that are tightly controlled at the level of production and in …

Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is
synthesized as an inactive precursor requiring processing by caspase-1 into an active …

Together with IL-12 or IL-15, interleukin-18 (IL-18) plays a major role in the production of
interferon-γ from T-cells and natural killer cells; thus, IL-18 is considered to have a major role …

Although IL-18 is an inducer of IFN-gamma and Th1 responses. IL-18 is a proinflammatory
cytokine by several criteria. In several animal models. antibodies that neutralize …

Interleukin 18 (IL-18) is a pro-inflammatory cytokine of the IL-1 family, whose activity is tightly
controlled at the level of production, as well as signalization. Notably, it is buffered by its …

Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of
innate and adaptive immune responses. IL-18 has attracted increasing attention as a key …

Publisher Summary Interleukin-18 (IL-18) is a multifunctional cytokine, the roles of which
extend over both acquired and innate immunity, and its major role has been thought to be …

IL-18 can be considered a proinflammatory cytokine mediating disease as well as an
immunostimulatory cytokine that is important for host defense against infection and cancer …

Abstract Interleukin (IL)-18, structurally similar to IL-1-, is a member of IL-1 superfamily of
cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid …

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …