Development of an intelligent, stimuli-responsive transdermal system for efficient delivery of Ibuprofen against rheumatoid arthritis

D Khan, M Qindeel, N Ahmed, MI Asad… - International Journal of …, 2021 - Elsevier
The present study aimed to fabricate and evaluate the therapeutic efficacy of pH-responsive
Ibuprofen (IB) nanoparticles (NPs) loaded transdermal hydrogel against rheumatoid arthritis …

Development of novel pH-sensitive nanoparticle-based transdermal patch for management of rheumatoid arthritis

D Khan, M Qindeel, N Ahmed, AU Khan, S Khan… - …, 2020 - Taylor & Francis
Aim: To formulate and evaluate a pH-responsive nanoparticle (NP)-based patch for efficient
transdermal delivery of flurbiprofen against rheumatoid arthritis. Materials & methods …

Biodegradable ingredient-based emulgel loaded with ketoprofen nanoparticles

R Gul, N Ahmed, N Ullah, MI Khan, A Elaissari… - AAPS …, 2018 - Springer
Biodegradable materials are extensively employed to design nanocarriers that mimic
extracellular environment in arthritis. The aim of this study was to formulate and characterize …

[HTML][HTML] Optimization of novel naproxen-loaded chitosan/carrageenan nanocarrier-based gel for topical delivery: Ex vivo, histopathological, and in vivo evaluation

S Noreen, F Pervaiz, A Ashames, M Buabeid… - Pharmaceuticals, 2021 - mdpi.com
Naproxen (NAP) is commonly used for pain, inflammation, and stiffness associated with
arthritis. However, systemic administration is linked with several gastrointestinal tract (GIT) …

[HTML][HTML] Investigation and Evaluation of the Transdermal Delivery of Ibuprofen in Various Characterized Nano-Drug Delivery Systems

J Myburgh, W Liebenberg, C Willers, A Dube, M Gerber - Pharmaceutics, 2023 - mdpi.com
The aim was to assess the suitability of three nano-based transdermal drug delivery systems
containing ibuprofen: a nano-emulsion, a nano-emulgel, and a colloidal suspension with …

Synthesis and characterization of an injectable microparticles integrated hydrogel composite biomaterial: In-vivo biocompatibility and inflammatory arthritis treatment

M Dhanka, V Pawar, DS Chauhan, NK Jain… - Colloids and Surfaces B …, 2021 - Elsevier
Polymeric hydrogels and microparticles have been widely used for localized drug delivery
applications for the treatment of arthritis. Nonetheless, owing to initial burst drug release …

Mitigation of rheumatic arthritis in a rat model via transdermal delivery of dapoxetine HCl amalgamated as a nanoplatform: in vitro and in vivo assessment

HF Salem, MM Nafady, RM Kharshoum… - International journal …, 2020 - Taylor & Francis
Purpose Dapoxetine HCl (DH), a selective serotonin reuptake inhibitor, may be useful for the
treatment of rheumatic arthritis (RA). The purpose of this study was to investigate the …

Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy

M Qindeel, MH Ullah, N Ahmed - Journal of Controlled Release, 2020 - Elsevier
At present, several drug molecules have been used for the treatment of rheumatoid arthritis
(RA). However, the utilization of these compounds through the oral and parenteral route is …

Superiority of microemulsion-based hydrogel for non-steroidal anti-inflammatory drug transdermal delivery: a comparative safety and anti-nociceptive efficacy study

MM Mehanna, KK Abla, S Domiati… - International Journal of …, 2022 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) represent the foundation of pain
management caused by inflammatory disorders. Nevertheless, their oral administration …

[HTML][HTML] Ibuprofen-Loaded Chitosan–Lipid Nanoconjugate Hydrogel with Gum Arabic: Green Synthesis, Characterisation, In Vitro Kinetics Mechanistic Release Study …

S Mahmood, SH Almurisi, K Al-Japairai, AR Hilles… - Gels, 2021 - mdpi.com
Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often
used to treat inflammation in general. When given orally, it produces gastrointestinal issues …