[HTML][HTML] Zinc and copper ions differentially regulate prion-like phase separation dynamics of pan-virus nucleocapsid biomolecular condensates

A Monette, AJ Mouland - Viruses, 2020 - mdpi.com
Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous
demonstrations that many cellular proteins phase-separate to form biomolecular …

[HTML][HTML] Pan-retroviral nucleocapsid-mediated phase separation regulates genomic RNA positioning and trafficking

A Monette, M Niu, L Chen, S Rao, RJ Gorelick… - Cell reports, 2020 - cell.com
The duality of liquid-liquid phase separation (LLPS) of cellular components into
membraneless organelles defines the nucleation of both normal and disease processes …

[HTML][HTML] Formation and function of liquid-like viral factories in negative-sense single-stranded RNA virus infections

JM Su, MZ Wilson, CE Samuel, D Ma - Viruses, 2021 - mdpi.com
Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to
organize intracellular membrane-less structures. Studies with non-segmented negative …

[HTML][HTML] Deconstructing virus condensation

N Lopez, G Camporeale, M Salgueiro… - PLoS …, 2021 - journals.plos.org
Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …

[HTML][HTML] Liquid biomolecular condensates and viral lifecycles: review and perspectives

TA Etibor, Y Yamauchi, MJ Amorim - Viruses, 2021 - mdpi.com
Viruses are highly dependent on the host they infect. Their dependence triggers processes
of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping …

[HTML][HTML] Liaisons dangereuses: Intrinsic Disorder in Cellular Proteins Recruited to Viral Infection-Related Biocondensates

G Bianchi, S Brocca, S Longhi, VN Uversky - International Journal of …, 2023 - mdpi.com
Liquid–liquid phase separation (LLPS) is responsible for the formation of so-called
membrane-less organelles (MLOs) that are essential for the spatio-temporal organization of …

[HTML][HTML] New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021 - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Phase separation in viral infections

H Li, C Ernst, M Kolonko-Adamska… - Trends in …, 2022 - cell.com
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …

[HTML][HTML] Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series

J Shorter - Journal of Biological Chemistry, 2019 - ASBMB
In recent years, there has been a jarring awakening that liquid–liquid phase separation
(LLPS) of key protein and nucleic acid scaffolds underpins the biogenesis of diverse …

[HTML][HTML] Evidence that the adenovirus single-stranded DNA binding protein mediates the assembly of biomolecular condensates to form viral replication compartments

P Hidalgo, A Pimentel, D Mojica-Santamaría… - Viruses, 2021 - mdpi.com
A common viral replication strategy is characterized by the assembly of intracellular
compartments that concentrate factors needed for viral replication and simultaneously …