MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of
gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched …

The central control of energy balance involves a highly regulated neuronal network within
the hypothalamus and the dorsal vagal complex. In these structures, pro-opiomelanocortin …

MicroRNAs (miRNAs) have recently been found to be critical regulators of metabolic
homeostasis. A study in Nature by Trajkovski et al.(2011) shows that the highly related …

The role of neuronal noncoding RNAs in energy control of the body is not fully understood.
The arcuate nucleus (ARC) of the hypothalamus comprises neurons regulating food intake …

MicroRNAs (miRNAs) are endogenous noncoding RNAs that downregulate gene
expression by inhibiting translation or promoting mRNA degradation. Although over one …

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …

AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity
and associated metabolic disorders. While many factors impacting central regulation of …

MicroRNAs (miRNAs) regulate many physiological processes including body growth.
Insulin/IGF signalling is the primary regulator of animal body growth, but the extent to which …

MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous
biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes …

The hypothalamus is a crucial central nervous system area controlling appetite, body weight
and metabolism. It consists in multiple neuronal types that sense, integrate and generate …