Recent discoveries from the past 15 years of human genetic association studies have
provided new insights into the common genetic basis of coronary artery disease and its risk …

An individual's susceptibility to atherosclerotic cardiovascular disease is influenced by
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …

Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …

Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale
genetic studies identified hundreds of genomic loci that affect the risk of coronary artery …

Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using
information on the genetic predisposition at an individual level might offer new possibilities …

Abstract Purpose of Review The purpose of this review is to understand the conceptual
basis and implications of polygenic risk scores (PRS) in assessing risk of future coronary …

Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Polygenic risk scores for the diagnosis and management of dy... : Current Opinion in
Endocrinology, Diabetes and Obesity Polygenic risk scores for the diagnosis and …

Polygenic risk scores represent a method of aggregating an individual's genetic information,
weighted by associations between genetic variants and disease outcomes identified from …