[HTML][HTML] An overview of NRF2-activating compounds bearing α, β-unsaturated moiety and their antioxidant effects
MC Egbujor, B Buttari, E Profumo… - International Journal of …, 2022 - mdpi.com
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …
Structural modification of C2-substituents on 1, 4-bis (arylsulfonamido) benzene or naphthalene-N, N′-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 …
Abstract The Keap1-Nrf2-ARE signaling pathway is an attractive therapeutic target for the
prevention and treatment of oxidative stress-associated diseases by activating the cellular …
prevention and treatment of oxidative stress-associated diseases by activating the cellular …
An updated patent review of Nrf2 activators (2020-present)
Z Zhao, R Dong, K Cui, Q You… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription
factor that controls the expression of numerous cytoprotective genes and regulates cellular …
factor that controls the expression of numerous cytoprotective genes and regulates cellular …
[HTML][HTML] NRF2 activation by nitrogen heterocycles: a review
Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2
LFMF Cardozo, LM Pedruzzi, P Stenvinkel… - Biochimie, 2013 - Elsevier
The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …
[HTML][HTML] The role of organosulfur compounds as Nrf2 activators and their antioxidant effects
Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for
cellular regulation against oxidative stress and inflammation, and therefore an attractive …
cellular regulation against oxidative stress and inflammation, and therefore an attractive …
Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)
ABSTRACT Introduction: The NF-E2-related factor-2 (Nrf2) is a critical transcription factor
that regulates the expression of many phase II and antioxidant genes to maintain the …
that regulates the expression of many phase II and antioxidant genes to maintain the …
[HTML][HTML] An overview of Nrf2 signaling pathway and its role in inflammation
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
B Ma, B Lucas, A Capacci, EYS Lin, JH Jones… - Bioorganic & Medicinal …, 2020 - Elsevier
Nrf2 is a transcription factor regulating expression of the Phase II Antioxidant Response and
plays an important role in neuroprotection and detoxification. Nrf2 activation is inhibited by …
plays an important role in neuroprotection and detoxification. Nrf2 activation is inhibited by …
Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities
Natural products with antioxidant and anti-inflammatory properties are important sources of
therapeutic agents. The nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …
therapeutic agents. The nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …