Ras homolog enriched in brain (Rheb1), a small GTPase, plays a crucial role in regulating
cell growth, differentiation, and survival. However, the role and mechanisms for Rheb1 in …

Background Cisplatin is a widely used and effective chemotherapeutic agent against cancer.
However, nephrotoxicity is one of the most common side effects of cisplatin, and it can …

Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is
increasing evidence that mitochondrial dysfunction plays an important role in cisplatin …

Abstract Ischemia-reperfusion (I/R) induced acute kidney injury (AKI), characterized by
excessive mitochondrial damage and cell apoptosis, remains a clinical challenge. Recent …

Abstract Toll‐like receptors (TLRs), which are essential components of the innate immune
response, play an important role in acute kidney injury (AKI). Toll‐like receptor 2 (TLR2) is …

Our preliminary work has revealed that vitamin D receptor (VDR) activation is protective
against cisplatin induced acute kidney injury (AKI). Ferroptosis was recently reported to be …

Acute kidney injury (AKI) has been associated with not only higher in-hospital mortality but
also the subsequent development of chronic kidney disease (CKD). Recent evidence has …

Acute kidney injury (AKI) is associated with high morbidity and mortality. Our previous study
has demonstrated that TMEM16A, a Ca2+-activated chloride channel, contributes to renal …

Cisplatin‐(CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin.
Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin …

Aims Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The
drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and …