Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal
disease in humans. Over the past several years, antibody therapy has emerged as a …

Filoviruses cause highly lethal viral hemorrhagic fever in humans and nonhuman primates.
Current immunotherapeutic options for filoviruses are mostly specific to Ebola virus (EBOV) …

The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has
highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody …

Out of an estimated 31,100 cases since their discovery in 1976, ebolaviruses have caused
approximately 13,000 deaths. The vast majority (∼ 11,000) of these occurred during the …

Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These
pathogens cause a rapidly progressing and severe viral disease with high mortality rates …

Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies
(MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a …

Ebola viruses can cause severe hemorrhagic fever in humans and nonhuman primates with
fatality rates up to 90%, and are identified as biosafety level 4 pathogens and CDC Category …

Abstract The 2013–2016 Ebola virus (EBOV) disease epidemic demonstrated the grave
consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV …

Ebola (EBOV), Marburg (MARV) and Sudan (SUDV) viruses are the three filoviruses which
have caused the most fatalities in humans. Transmission from animals into the human …

The filoviruses Ebola virus and Marburg virus are among the most dangerous pathogens in
the world. Both viruses cause viral hemorrhagic fever, with case fatality rates of up to 90 …