Τhe expression of the critical initiator cytokine TNF-α was strongly upregulated in vivo in
acute necrotic pancreatitis (AP) in rodents and in vitro in TNF-α activated acinar AR42J cells …

We have demonstrated that Kupffer cell–derived tumor necrosis factor (TNF) mediates
pancreatitis-associated liver injury. The aim of this study was to determine the role of p38 …

BACKGROUND & AIMS: The signaling mechanisms that regulate trypsinogen activation and
inflammation in acute pancreatitis (AP) are unclear. We explored the involvement of the …

Background Aberrant regulation of nuclear factor-κB (NF-κB) and the signaling pathways
that regulate its activity have been found to be involved in various pathologies, particularly …

To elucidate whether pancreatic acinar cell submitted to stress is able to express TNF-α, we
studied TNF-α mRNA expression by Northern blot and in situ hybridization in healthy …

TNF-α plays a pivotal role in the pathogenesis of acute pancreatitis. Recent studies have
shown that TNF-α inhibition significantly ameliorates the course of experimental acute …

We explored the pathophysiological roles of IFN-γ in cerulein-induced acute pancreatitis. In
wild-type (WT) mice, cerulein injection caused acute pancreatitis as evidenced by increased …

Transcription factor nuclear factor-κB (NF-κB) is activated in cerulein pancreatitis and
mediates cytokine expression. The role of transcription factor activation in other models of …

Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show
that transcription factor nuclear factor-κB (NF-κB), which regulates these processes, is …

Proinflammatory cytokines, such as tumour necrosis factor α (TNFα), play fundamental roles
in the pathogenesis of acute pancreatitis (AP). The aim of this study was to determine if …