Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …

Primary prevention in individuals at Clinical High Risk for psychosis (CHR-P) can ameliorate
the course of psychotic disorders. Further advancements of knowledge have been slowed …

Understanding whether and how the schizophrenia polygenic risk score (SZ PRS) predicts
course of illness could improve diagnosis and prognostication in psychotic disorders. We …

Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …

Twenty percent of individuals at clinical high risk for psychosis (CHR-P) develop the disorder
within 2 years. Extensive research has explored the factors that differentiate those who …

BackgroundThere is increasing evidence for shared genetic susceptibility between
schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases …

BackgroundThe liability-threshold model of psychosis risk predicts stronger phenotypic
manifestation of the polygenic risk score (PRS) in the healthy relatives of patients, as …

Background: The period preceding the first psychotic episode is regarded as a promising
period for intervention. We aimed to develop an optimized prediction model of a first …

Importance Individuals can be classified as being at clinical high risk (CHR) for psychosis if
they meet at least one of the ultra–high-risk (UHR) inclusion criteria (brief limited intermittent …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …