Genetic variants associated with longitudinal changes in brain structure across the lifespan

RM Brouwer, M Klein, KL Grasby, HG Schnack… - Nature …, 2022 - nature.com
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Common brain disorders are associated with heritable patterns of apparent aging of the brain

T Kaufmann, D van der Meer, NT Doan… - Nature …, 2019 - nature.com
Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …

[HTML][HTML] Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

E Hofer, GV Roshchupkin, HHH Adams, MJ Knol… - Nature …, 2020 - nature.com
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …

Voxelwise genome-wide association study (vGWAS)

JL Stein, X Hua, S Lee, AJ Ho, AD Leow, AW Toga… - neuroimage, 2010 - Elsevier
The structure of the human brain is highly heritable, and is thought to be influenced by many
common genetic variants, many of which are currently unknown. Recent advances in …

Age-related differences in brain morphology and the modifiers in middle-aged and older adults

L Zhao, W Matloff, K Ning, H Kim, ID Dinov… - Cerebral …, 2019 - academic.oup.com
Brain structural morphology differs with age. This study examined age-differences in surface-
based morphometric measures of cortical thickness, volume, and surface area in a well …

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …

B Zhao, T Luo, T Li, Y Li, J Zhang, Y Shan, X Wang… - Nature …, 2019 - nature.com
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

[HTML][HTML] Differential aging analysis in human cerebral cortex identifies variants in TMEM106B and GRN that regulate aging phenotypes

H Rhinn, A Abeliovich - Cell systems, 2017 - cell.com
Human age-associated traits, such as cognitive decline, can be highly variable across the
population, with some individuals exhibiting traits that are not expected at a given …

Genetic architecture of subcortical brain structures in 38,851 individuals

CL Satizabal, HHH Adams, DP Hibar, CC White… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects

DP Hibar, JL Stein, O Kohannim, N Jahanshad… - Neuroimage, 2011 - Elsevier
Imaging traits provide a powerful and biologically relevant substrate to examine the
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

V Warrier, EM Stauffer, QQ Huang, EM Wigdor… - Nature …, 2023 - nature.com
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …