Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical
and biochemical signals in their local microenvironment to regulate genomic programs via …

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular
responses that control cell fate changes. Mechanical forces also physically distort …

Living cells and tissues experience various complex modes of forces that are important in
physiology and disease. However, how different force modes impact gene expression is …

Tissue homeostasis requires maintenance of functional integrity under stress. A central
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how …

Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress,
compression, differential tissue rigidity and strain, to which they adapt by engaging …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

The nucleus houses, organizes, and protects chromatin to ensure genome integrity and
proper gene expression, but how the nucleus adapts mechanically to changes in the …

Mechanical tension generated within the cytoskeleton of living cells is emerging as a critical
regulator of biological function in diverse situations ranging from the control of chromosome …