Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA. 1 infection of K18-hACE2 mice

A Carolin, CR Bishop, K Yan, W Nguyen, B Tang… - bioRxiv, 2024 - biorxiv.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus
Disease 2019 (COVID-19), which can result in severe disease often characterised by …

Transcriptomic landscapes of SARS-CoV-2-infected and bystander lung cells reveal a selective upregulation of NF-κB-dependent coding and non-coding proviral …

U Szachnowski, A Bhargava, M Chazal, D Foretek… - bioRxiv, 2022 - biorxiv.org
Detailed knowledge of cellular networks that are modulated by Severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is needed to understand viral replication and host …

[HTML][HTML] A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

KH Dinnon III, SR Leist, K Okuda, H Dang, EJ Fritch… - BioRxiv, 2022 - ncbi.nlm.nih.gov
COVID-19 survivors develop post-acute sequelae of SARS-CoV-2 (PASC), but the
mechanistic basis of PASC-associated lung abnormalities suffers from a lack of longitudinal …

A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice

S Choi, J Lee, S Kim, YW Lee, GC Kim, SM Hong… - …, 2024 - thelancet.com
Background The global pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million …

[HTML][HTML] A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

TM Delorey, CGK Ziegler, G Heimberg, R Normand… - Biorxiv, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute
lung injury and acute respiratory distress syndrome, or direct complications resulting in …

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

S Peidli, G Nouailles, E Wyler, JM Adler, S Kunder… - Cell Reports, 2024 - cell.com
A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and
of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be …

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

RA Grant, L Morales-Nebreda, NS Markov… - bioRxiv, 2020 - biorxiv.org
Some patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-
2) develop severe pneumonia and the acute respiratory distress syndrome (ARDS). Distinct …

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

DK Singh, E Aladyeva, S Das, B Singh… - Nature …, 2022 - nature.com
Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-
related death necessitates better understanding of the early viral dynamics, host responses …

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

B Cong, X Dong, Z Yang, P Yu, Y Chai, J Liu, M Zhang… - Biorxiv, 2022 - biorxiv.org
While SARS-CoV-2 pathogenesis has been intensively investigated, the host mechanisms
of viral clearance and inflammation resolution are still elusive because of the ethical …