Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …

Identification of correlates of protection for infectious diseases including malaria is a major
challenge and has become one of the main obstacles in developing effective vaccines. We …

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable
of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm …

The success of the first licensed mRNA-based vaccines against COVID-19 has created a
widespread interest on mRNA technology for vaccinology. As expected, the number of …

Sterile immunity against live Plasmodium infection can be achieved by immunization with
radiation-attenuated sporozoites. This protection is known to be mediated in part by antigen …

Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …