Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

Objective: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in
cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms …

Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …

Background The NOD-like receptor family pyrin domain-containing 3 (NLRP3)
inflammasome is an important mediator of neuroinflammatory responses that regulates …

Objective Current therapies for ischemia/reperfusion are insufficient because of our poor
understanding of the mechanisms of brain injury after ischemic stroke. As a vital component …

Background: Subtypes of microglia/macrophage regulate the inflammation in the opposite
direction during ischemic stroke. JAK2/STAT3 signaling pathway participates in the …

Background Idebenone is a well-appreciated mitochondrial protectant while the
mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) …

Hemorrhagic stroke is a devastating disease with high morbidity and mortality. There is still a
lack of effective therapeutic approach. The recent studies have shown that the innate …

Abstract Background Stroke affects 3–4% of adults and kills numerous people each year.
Recovering blood flow with minimal reperfusion-induced injury is crucial. However, the …

Resveratrol has been reported to protect against cerebral ischemia/reperfusion (I/R) injury in
rats, but the underlying mechanism is unclear. In the current study, we examined whether …