Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Structural biology of SARS-CoV-2 and implications for therapeutic development

H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …

[HTML][HTML] Structural characterization of SARS-CoV-2: where we are, and where we need to be

G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

Structural insights into SARS-CoV-2 proteins

R Arya, S Kumari, B Pandey, H Mistry, SC Bihani… - Journal of molecular …, 2021 - Elsevier
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …

[HTML][HTML] Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

AAT Naqvi, K Fatima, T Mohammad, U Fatima… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The sudden emergence of severe respiratory disease, caused by a novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently become a public health …

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Update on the target structures of SARS-CoV-2: A systematic review

M Prajapat, P Sarma, N Shekhar… - Indian Journal of …, 2020 - journals.lww.com
Abstract Knowledge of structural details is very much essential from the drug-design
perspective. In the systematic review, we systematically reviewed the structural basis of …

SARS-CoV-2: insight in genome structure, pathogenesis and viral receptor binding analysis–an updated review

EA Bhat, N Sajjad, A Ali, FM Aldakheel… - International …, 2021 - Elsevier
The novel coronavirus disease (COVID-19) a global pandemic outbreak is an emerging new
virus accountable for respiratory illness caused by SARS-CoV-2, originated in Wuhan city …

Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets

MT Khan, M Irfan, H Ahsan, A Ahmed, AC Kaushik… - Intervirology, 2021 - karger.com
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic
has resulted in thousands of infections and deaths worldwide. Several therapies are …

[PDF][PDF] Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms

NC Huston, H Wan, MS Strine, RCA Tavares, CB Wilen… - Molecular cell, 2021 - cell.com
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …