Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF‐κB and AP‐1 activation and IL‐8 and VEGF expression …

CC Bancroft, Z Chen, J Yeh, JB Sunwoo… - … journal of cancer, 2002 - Wiley Online Library
We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and
vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors …

Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-κB signal …

CC Bancroft, Z Chen, G Dong, JB Sunwoo, N Yeh… - Clinical Cancer …, 2001 - AACR
Abstract Interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) promote tumor
angiogenesis, growth, and metastasis and are coexpressed by human head and neck …

Constitutive activation of transcription factors NF‐κB, AP‐1, and NF‐IL6 in human head and neck squamous cell carcinoma cell lines that express pro‐inflammatory …

FG Ondrey, G Dong, J Sunwoo, Z Chen… - … in cooperation with …, 1999 - Wiley Online Library
We previously reported that human head and neck squamous cell carcinomas (HNSCCs)
express the pro‐inflammatory and pro‐angiogenic cytokines interleukin (IL)‐1α, IL‐6, IL‐8 …

MAPK and PI3K signalling differentially regulate angiogenic and lymphangiogenic cytokine secretion in squamous cell carcinoma of the head and neck

S Luangdilok, C Box, K Harrington… - European journal of …, 2011 - Elsevier
Vascular endothelial growth factors (VEGF-C and VEGF-A) play important roles in tumour-
induced lymphangiogenesis and angiogenesis, respectively, key processes implicated in …

Role of angiogenic factors: coexpression of interleukin‐8 and vascular endothelial growth factor in patients with head and neck squamous carcinoma

RJ Eisma, JD Spiro, DL Kreutzer - The Laryngoscope, 1999 - Wiley Online Library
Abstract Objective/Hypothesis: Angiogenesis has been used as a prognostic indicator in a
variety of cancers and is believed to be controlled by angiogenic factors, including the …

IL (interleukin)-1α promotes nuclear factor-κB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas

JS Wolf, Z Chen, G Dong, JB Sunwoo, CC Bancroft… - Clinical Cancer …, 2001 - AACR
Abstract Interleukin 1α (IL-1α) is an important regulatory cytokine, the release of which after
an injury can induce activation of transcription factors nuclear factor (NF) κB and activator …

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer

Z Chen, PS Malhotra, GR Thomas, FG Ondrey… - Clinical cancer …, 1999 - AACR
Altered immune, inflammatory, and angiogenesis responses are observed in patients with
head and neck squamous cell carcinoma (HNSCC), and many of these responses have …

IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma

MG Slomiany, LA Black, MM Kibbey, TA Day… - Biochemical and …, 2006 - Elsevier
Elevated vascular endothelial growth factor (VEGF) levels correlate with increased
progression and poor prognosis of head and neck squamous cell carcinomas (HNSCC) …

Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα

G Sethi, KS Ahn, MM Chaturvedi, BB Aggarwal - Oncogene, 2007 - nature.com
Overexpression of epidermal growth factor (EGF) receptor and constitutive activation of
nuclear factor-κB (NF-κB) are frequently encountered in tumor cells. Although EGF has been …

Epigallocatechin‐3‐gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR‐related pathways of signal transduction

M Masuda, M Suzui, JTE Lim, A Deguchi… - Journal of …, 2002 - Wiley Online Library
In a recent study on head and neck squamous cell carcinoma (HNSCC) cells we found that
epigallocatechin‐3‐gallate (EGCG), a major biologically active component of green tea …