Alternative splicing contributes to adaptation and divergence in many species. However, it
has not been possible to directly compare splicing between modern and archaic hominins …

Humans coexisted and interbred with other hominins which later became extinct. These
archaic hominins are known to us only through fossil records and for two cases, genome …

Identification of functional genetic variants and elucidation of their regulatory mechanisms
represent significant challenges of the post-genomic era. A poorly understood topic is the …

Comparative studies of gene regulation suggest an important role for natural selection in
shaping gene expression patterns within and between species. Most of these studies …

Ancient DNA provides a powerful window into the biology of extant and extinct species,
including humans' closest relatives: Denisovans and Neanderthals. Here, we review what is …

Alternative splicing (AS) has the potential to greatly expand the functional repertoire of
mammalian transcriptomes. However, few variant transcripts have been characterized …

How species with similar repertoires of protein-coding genes differ so markedly at the
phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate …

Processed pseudogenes (PPGs) are cDNA sequences that were generated through reverse
transcription of mature, spliced mRNAs and have subsequently been reinserted at a new …

A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Abstract Changes in gene regulation were a major driver of the divergence of archaic
hominins (AHs)—Neanderthals and Denisovans—and modern humans (MHs). The three …