Regional-and cell type-specific changes of the human brain during aging

Y Chen, G Zu, BLF Zhang, Z Bai, Q Liu, W Li… - Human Brain, 2023 - eaapublishing.org
As individuals age, cognitive decline becomes more prominent, concomitant with an
elevated susceptibility to neurodegenerative diseases and dementia. Additionally …

Cellular mechanisms in brain aging: Focus on physiological and pathological aging

L Aguilar-Hernández, R Alejandre… - Journal of Chemical …, 2023 - Elsevier
Aging is a natural phenomenon characterized by accumulation of cellular damage and
debris. Oxidative stress, cellular senescence, sustained inflammation, and DNA damage are …

Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect

D Bano, M Agostini, G Melino, P Nicotera - Molecular neurobiology, 2011 - Springer
Cognitive decline associated with ageing and age-related disorders emerges as one of the
greatest health challenges in the next decades. To date, the molecular mechanisms …

Brain aging: a critical reappraisal

MK Thakur, A Konar, A Gautam - Brain aging and therapeutic interventions, 2012 - Springer
Despite remarkable scientific advancements in recent years, much about the human brain
still remains a mystery, particularly in the context of brain aging and associated disorders …

Brain aging: A Ianus‐faced player between health and neurodegeneration

S Vanni, A Colini Baldeschi, M Zattoni… - Journal of …, 2020 - Wiley Online Library
Neurodegenerative diseases are incurable debilitating disorders characterized by structural
and functional neuronal loss. Approximately 30 million people are affected worldwide, and …

Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes

J Lee, HJ Kim - Frontiers in aging neuroscience, 2022 - frontiersin.org
Aging is accompanied by many changes in brain and contributes to progressive cognitive
decline. In contrast to pathological changes in brain, normal aging brain changes have …

Brain Aging and Glial Cells: What Is the Link?

K Smimih, C Azzouhri, FEZ Saad… - … and Function of Glial …, 2024 - igi-global.com
Brain aging is a complicated and diversified process that includes an ongoing decline in
cognitive performance as well as various cellular and molecular changes in the brain …

The many faces of brain aging

L Marsili, M Canevelli… - Frontiers in Aging …, 2022 - frontiersin.org
Brain aging is characterized by changes at all levels, from molecules to morphology,
reflected by reduced brain size, altered vasculature, and declines in motor and cognitive …

[HTML][HTML] Glial alterations in aging and Alzheimer's Disease: a novel basis to understand, prevent and treat the degenerative process

A Toledano-Díaz, MI Álvarez, A Toledano - OBM Geriatrics, 2020 - lidsen.com
Neurons, from the time of their birth until their death, are always accompanied by neuroglial
cells, maintaining very close morphological and functional relationships among themselves …

Brain Aging

MA Cherdak - Advances in Gerontology, 2023 - Springer
Brain aging is part of the aging of the whole body, largely determining the success of
general aging and the quality of life of an older person. Brain aging is a complex …