IMP-1 metallo-β-lactamase (class B) is a plasmid-borne zinc metalloenzyme that efficiently
hydrolyzes β-lactam antibiotics, including carbapenems, rendering them ineffective …

The metallo-β-lactamase IMP-1 catalyzes the hydrolysis of a broad range of β-lactam
antibiotics to provide bacterial resistance to these compounds. In this study, 29 amino acid …

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of
IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship …

In an effort to probe for metal binding to metallo-β-lactamase (MβL) IMP-1, the enzyme was
overexpressed, purified, and characterized. The resulting enzyme was shown to bind 2 …

Abstract IMP-1 metallo-β-lactamase is a transferable carbapenem-hydrolyzing enzyme
found in some clinical isolates of Pseudomonas aeruginosa, Serratia marcescens and …

Metallo-β-lactamase IMP-1 is a di-Zn (II) metalloenzyme that efficiently hydrolyzes β-lactam
antibiotics. Wild-type (WT) IMP-1 has a conserved Asp-120 (81) in the active site, which …

SYNTHESIS AND SAR OF THIOESTER AND THIOL INHIBITORS OF IMP-1 METALLO-~-LACTAMASE
Page 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Pergamon Bioorganic & Medicinal …

Metallo β-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the
hydrolysis of β-lactam antibiotics. This relatively new form of resistance is spreading …

IMP‐1 β‐lactamase is a zinc metallo‐enzyme encoded by the transferable blaIMP‐1 gene,
which confers resistance to virtually all β‐lactam antibiotics including carbapenems. To …

In the course of surveying for the carbapenem-hydrolyzing metallo-β-lactamase gene bla
IMP in pathogenic bacteria by the PCR method, we detected a gene encoding a variant …