Endoplasm reticulum stress and inflammation response have been found to be linked to
cerebral ischemia‐reperfusion (IR) injury. Sphingosine kinase 1 (SPHK1) has been reported …

Sphingosine kinases (Sphks) are the rate-limiting kinases in the generation of sphingosine-
1-phosphate, which is a well-established intracellular pro-survival lipid mediator. Sphk2 has …

The pathogenesis of inflammation in the central nervous system (CNS), which contributes to
numerous neurodegenerative diseases and results in encephalopathy and …

Abstract Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating
sphingosine into sphingosine1-phosphate (S1P), plays an important role in mediating post …

Background Hepatic ischemia/reperfusion (I/R) injury remains a significant problem in
clinical practice. Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to sphingosine …

Microglial hyperactivation mediated by sphingosine kinase 1/sphingosine‐1‐phosphate
(SphK1/S1P) signalling and the consequent inflammatory mediator production serve as the …

Aim Endoplasmic reticulum (ER) stress is common in different human pathologies, including
cardiac diseases. Sphingosine kinase‐1 (SPHK1) represents an important player in cardiac …

Background Microglial activation is one of the causative factors of neuroinflammation in
cerebral ischemia/reperfusion (IR). Sphingosine kinase 1 (Sphk1), a key enzyme …

White matter lesions (WML) are thought to contribute to vascular cognitive impairment in
elderly patients. Growing evidence show that failure of myelin formation arising from the …

Microglial activation has been implicated as one of the causative factors for
neuroinflammation in various neurodegenerative diseases. The sphingolipid metabolic …