Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial
tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

Cells perceive their microenvironment not only through soluble signals but also through
physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined …

Mammalian cells must integrate environmental cues to determine coherent physiological
responses. The transcription factors Myc and YAP–TEAD act downstream from mitogenic …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Organ size is controlled by the concerted action of biochemical and physical processes.
Although mechanical forces are known to regulate cell and tissue behavior, as well as …

The evolution of a solid tumor is fueled by genetic aberrations. Yet, the tumor environment
often dominates over the effects of genetics: normal tissues have powerful tumor …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …