Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

One of the key breakthroughs in the epigenetics/chromatin field in the last several years was
the identification of enzymes capable of removing the methyl group from methylated lysines …

Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

Histone lysine‐specific demethylase 1 (LSD1) is the first discovered and reported histone
demethylase by Dr. Shi Yang's group in 2004. It is classified as a member of amine oxidase …

It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A)
roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

LSD1 is a recently identified human lysine (K)-specific histone demethylase. LSD1 is
associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80, a …

Abstract Lysine-specific demethylase 1 (LSD1) targets mono-or di-methylated histone H3K4
and H3K9 as well as non-histone substrates and functions in the regulation of gene …

Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great
number of histone demethylases have been recognized and shown to play important roles …

Epigenetic silencing of gene expression is important in cancer. Aberrant DNA CpG island
hypermethylation and histone modifications are involved in the aberrant silencing of tumour …