Compounds with therapeutic potential against novel respiratory 2019 coronavirus

MA Martinez - Antimicrobial agents and chemotherapy, 2020 - Am Soc Microbiol
Currently, the expansion of the novel human respiratory coronavirus (known as SARS-CoV-
2 [severe acute respiratory syndrome coronavirus 2], COVID-2019 [coronavirus disease …

[HTML][HTML] Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses

ES Amirian, JK Levy - One health, 2020 - Elsevier
Recent international epidemics of coronavirus-associated illnesses underscore the urgent
medical and public health need for vaccine development and regulatory body approved …

Remdesivir metabolite GS-441524 effectively inhibits SARS-CoV-2 infection in mouse models

Y Li, L Cao, G Li, F Cong, Y Li, J Sun… - Journal of medicinal …, 2021 - ACS Publications
The outbreak of coronavirus disease 2019 (COVID-19) has resulted in a global pandemic
due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Remdesivir against COVID-19 and other viral diseases

JJ Malin, I Suárez, V Priesner… - Clinical microbiology …, 2020 - Am Soc Microbiol
Patients and physicians worldwide are facing tremendous health care hazards that are
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …

A review on remdesivir: a possible promising agent for the treatment of COVID-19

SMR Hashemian, T Farhadi… - Drug design, development …, 2020 - Taylor & Francis
Abstract The novel coronavirus 2019 (2019-nCoV), formally named severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a novel human infectious coronavirus. The …

Remdesivir: review of pharmacology, pre‐clinical data, and emerging clinical experience for COVID‐19

SCJ Jorgensen, R Kebriaei… - … : The Journal of Human …, 2020 - Wiley Online Library
The global pandemic of novel coronavirus disease 2019 (COVID‐19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has created an urgent need for …

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

A Schäfer, DR Martinez, JJ Won, RM Meganck… - Science Translational …, 2022 - science.org
The coronavirus disease 2019 (COVID-19) pandemic remains uncontrolled despite the
rapid rollout of safe and effective severe acute respiratory syndrome coronavirus 2 (SARS …

A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2

A Simonis, SJ Theobald, G Fätkenheuer… - EMBO molecular …, 2021 - embopress.org
The ongoing SARS‐CoV‐2 pandemic stresses the need for effective antiviral drugs that can
quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By …

A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir

C Liang, L Tian, Y Liu, N Hui, G Qiao, H Li, Z Shi… - European journal of …, 2020 - Elsevier
Abstract Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor
that can be used to treat a variety of RNA virus infections, is expected to be an effective …

Remdesivir: from Ebola to COVID-19

MG Santoro, E Carafoli - Biochemical and biophysical research …, 2021 - Elsevier
Human coronaviruses (HCoV) were discovered in the 1960s and were originally thought to
cause only mild upper respiratory tract diseases in immunocompetent hosts. This view …