Severe bacterial pneumonia leads to acute respiratory distress syndrome (ARDS), with a
high incidence rate and mortality. It is well-known that continuous and dysregulated …

Peptidoglycan (PGN) recognition proteins (PGLYRPs) are a highly conserved group of host
defense proteins in insects and mammals that sense bacterial cell wall PGN and act …

Streptococcus pneumoniae is the most frequent cause of community-acquired pneumonia.
Endogenous host defense molecules such as peptidoglycan recognition protein 4 …

Pneumonia is a leading cause of morbidity and mortality. While inflammation is a host
protective response that ensures bacterial clearance, a finely regulated response is …

Introduction. Sepsis is characterized by an infection-caused acute inflammatory response,
which is usually accompanied by multiple organ failure, especially lung injury. During …

Background Acute lung injury (ALI) is a severe organ dysfunction caused by sepsis.
WIN55212-2 (WIN) is a cannabinoid receptor agonist. Activation of cannabinoid type 2 …

The lung is the first and most frequent organ to fail among sepsis patients. The mortality rate
of sepsis‐related acute lung injury (ALI) is high. Despite appropriate antimicrobial therapy …

Sepsis is a potentially fatal systemic inflammatory response syndrome caused by infection.
In this study, we evaluated the effects of MCP-induced protein 1 (MCPIP1), a recently …

Acute lung injury (ALI) is mostly relevant to acute and severe lung inflammation. We first
utilized lipopolysaccharide (LPS) to induce mice for establishing a mouse model of ALI and …

This study tested the hypothesis that recombinant granulocyte-macrophage colony-
stimulating factor (GM-CSF) enhances polymorphonuclear neutrophils (PMNs) via …