Cancer is a highly complex disease due to the disruption of tissue architecture. Thus,
tissues, and not individual cells, are the proper level of observation for the study of …

Cancer begins to be recognized as a highly complex disease, and advanced knowledge of
the carcinogenic process claims to be acquired by means of supragenomic strategies …

Recent studies have shown that fractal geometry, a vocabulary of irregular shapes, can be
useful for describing the pathological architecture of tumors and, perhaps more surprisingly …

Through several examples selected from functional and pathological cells and tissues,
including surface, cytoplasmic and nuclear membranes one will focus on the application of …

Living structures may be described as being in a self-organizing, fluctuating steady-state far
from equilibrium. 1 Self-organization and a state far from equilibrium are characteristics of …

This volume highlights the growing power and efficacy of the fractal geometry in
understanding how to analyze living phenomena and complex shapes. In March 2000 …

The irregularity and self-similarity under scale changes are the main attributes of the
morphologic complexity of cells and tissues, either normal or pathologic. In other words, the …

The extension of the concepts of Fractal Geometry (Mandelbrot [1983]) toward the life
sciences has led to significant progress in understanding complex functional properties and …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

A novel parameter called expansion coefficient has been defined to measure both
connectivity and collectivity in a population of cells conquering the available space and self …