Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

282 BECKER, RAIVIO, and SEEGMILLER critical roles for this high-energy sugar phosphate
both as a substrate in the synthesis of nucleotide compounds and as a regulatory …

A procedure is described for a 450-fold purification of 5-phosphoribosyl α-1-pyrophosphate
(PRPP) synthetase from cells of Salmonella typhimurium LT-2. A sedimentation coefficient (s …

Phosphoribosylpyrophosphate (PRPP) synthetase participates in the biosynthesis in
bacteria of purine nucleotides, pyrimidine nucleotides, tryptophan, histidine, and the pyridine …

Phosphoribosyl‐diphosphate (PPRibP) synthetase from Bacillus subtilis has been purified to
near homogeneity from an Escherichia coli Δprs strain bearing the cloned B. subtilis prs …

PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide
synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5 …

Purine phosphoribosyltransferases (PRTs) 1 of microbes and mammals are enzymes that
catalyze the recovery of preformed bases for use in cellular metabolism. In free living …

The genetic and functional basis of phosphoribosylpyrophosphate synthetase (PRS)
superactivity associated with purine nucleotide inhibitor-resistance was studied in six …

A mutant of Escherichia coli harboring a temperature-labile phosphoribosylpyrophosphate
(PRPP) synthetase was characterized. Despite the lack of a detectable PRPP pool or PRPP …

Conditions are described where 5-phosphoribosyl-α-1-pyrophosphate (PRPP) can be
determined by thin-layer chromatographic methods commonly used for the determination of …