Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function

EF Morgan, ZD Mason, KB Chien, AJ Pfeiffer… - Bone, 2009 - Elsevier
Non-invasive characterization of fracture callus structure and composition may facilitate
development of surrogate measures of the regain of mechanical function. As such …

Micro-computed tomography assessment of the progression of fracture healing in mice

KR O'Neill, CM Stutz, NA Mignemi, MC Burns… - Bone, 2012 - Elsevier
The mouse fracture model is ideal for research into the pathways of healing because of the
availability of genetic and transgenic mice and the ability to create cell-specific genetic …

Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis

SJ Shefelbine, U Simon, L Claes, A Gold, Y Gabet… - Bone, 2005 - Elsevier
Assessment of fracture healing is a common problem in orthopaedic practice and research.
To determine the effectiveness of certain treatments, drugs, mechanical loads, or …

Influences of age and mechanical stability on volume, microstructure, and mineralization of the fracture callus during bone healing: is osteoclast activity the key to age …

M Mehta, P Strube, A Peters, C Perka, D Hutmacher… - Bone, 2010 - Elsevier
Earlier studies have shown that the influence of fixation stability on bone healing diminishes
with advanced age. The goal of this study was to unravel the relationship between …

Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography

JS Nyman, S Munoz, S Jadhav, A Mansour… - Journal of …, 2009 - Elsevier
Although fracture healing is frequently studied in pre-clinical models of long bone fractures
using rodents, there is a dearth of objective quantitative techniques to assess successful …

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

E Wehrle, DC Tourolle né Betts, GA Kuhn… - Scientific reports, 2019 - nature.com
Longitudinal in vivo micro-computed tomography (micro-CT) is of interest to non-invasively
capture the healing process of individual animals in preclinical fracture healing studies …

Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue

S Judex, S Boyd, YX Qin, L Miller, R Müller… - Current osteoporosis …, 2003 - Springer
Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a
deterioration of bone strength. However, the failure of the bone tissue to withstand functional …

Prediction of properties of fracture callus by measurement of mineral density using micro-bone densitometry.

HT Aro, BW Wippermann, SF Hodgson, HW Wahner… - JBJS, 1989 - journals.lww.com
An experiment was designed to determine whether the material properties of fracture callus
can be predicted by the measurement of mineral density. Rat tibiae that had a closed …

Noninvasive monitoring techniques for quantitative description of callus mineral content and mechanical properties.

MD MARKEL, EYS CHAO - Clinical Orthopaedics and Related …, 1993 - journals.lww.com
The noninvasive evaluation of fracture healing may allow more precise timing of fixation
device removal, quantitative recommendations for weight bearing, and the prediction of …

Measurement of fracture callus material properties via nanoindentation

PL Leong, EF Morgan - Acta biomaterialia, 2008 - Elsevier
In bone fracture healing, the extent to which the injured bone regains stability and strength
depends on the mechanical properties of the tissues that are formed during healing. While …