A review of statistical methods for prediction of proteolytic cleavage
DA duVerle, H Mamitsuka - Briefings in bioinformatics, 2012 - academic.oup.com
A fundamental component of systems biology, proteolytic cleavage is involved in nearly all
aspects of cellular activities: from gene regulation to cell lifecycle regulation. Current …
aspects of cellular activities: from gene regulation to cell lifecycle regulation. Current …
Cascleave: towards more accurate prediction of caspase substrate cleavage sites
Motivation: The caspase family of cysteine proteases play essential roles in key biological
processes such as programmed cell death, differentiation, proliferation, necrosis and …
processes such as programmed cell death, differentiation, proliferation, necrosis and …
A multi-factor model for caspase degradome prediction
LJK Wee, JC Tong, TW Tan, S Ranganathan - BMC genomics, 2009 - Springer
Background Caspases belong to a class of cysteine proteases which function as critical
effectors in cellular processes such as apoptosis and inflammation by cleaving substrates …
effectors in cellular processes such as apoptosis and inflammation by cleaving substrates …
Pripper: prediction of caspase cleavage sites from whole proteomes
M Piippo, N Lietzén, OS Nevalainen, J Salmi… - BMC …, 2010 - Springer
Background Caspases are a family of proteases that have central functions in programmed
cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate …
cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate …
Toward more accurate prediction of caspase cleavage sites: a comprehensive review of current methods, tools and features
As one of the few irreversible protein posttranslational modifications, proteolytic cleavage is
involved in nearly all aspects of cellular activities, ranging from gene regulation to cell life …
involved in nearly all aspects of cellular activities, ranging from gene regulation to cell life …
Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods
The roles of proteolytic cleavage have been intensively investigated and discussed during
the past two decades. This irreversible chemical process has been frequently reported to …
the past two decades. This irreversible chemical process has been frequently reported to …
Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates
Caspases are enzymes belonging to a conserved family of c ysteine-dependent asp artic-
specific prote ases that are involved in vital cellular processes and play a prominent role in …
specific prote ases that are involved in vital cellular processes and play a prominent role in …
PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy
Proteases are enzymes that specifically cleave the peptide backbone of their target proteins.
As an important type of irreversible post-translational modification, protein cleavage …
As an important type of irreversible post-translational modification, protein cleavage …
Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets
Motivation: Caspases and granzyme B (GrB) are important proteases involved in
fundamental cellular processes and play essential roles in programmed cell death, necrosis …
fundamental cellular processes and play essential roles in programmed cell death, necrosis …
GraBCas: a bioinformatics tool for score-based prediction of Caspase-and Granzyme B-cleavage sites in protein sequences
Caspases and granzyme B are proteases that share the primary specificity to cleave at the
carboxyl terminal of aspartate residues in their substrates. Both, caspases and granzyme B …
carboxyl terminal of aspartate residues in their substrates. Both, caspases and granzyme B …