[HTML][HTML] SARS-CoV-2 ORF7a protein blocks virusclearance by regulating autophagy: SARS-CoV-2 ORF7a blocks virus clearance by regulating autophagy

H Liu, Q Li, L Li - Acta Biochimica et Biophysica Sinica, 2023 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a serious public health threat …

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

P Hou, X Wang, H Wang, T Wang, Z Yu, C Xu, Y Zhao… - Autophagy, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

[HTML][HTML] The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …

SARS‐CoV‐2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

S Li, X Li, H Liang, K Yu, J Zhai, M Xue… - Journal of Medical …, 2023 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) continues to pose a major threat to
public health worldwide. Although many studies have clarified the severe acute respiratory …

[HTML][HTML] ORF3a-mediated incomplete autophagy facilitates severe acute respiratory syndrome coronavirus-2 replication

Y Qu, X Wang, Y Zhu, W Wang, Y Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for
the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to …

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication

Y Qu, X Wang, Y Zhu, Y Wang, X Yang, G Hu, C Liu… - bioRxiv, 2020 - biorxiv.org
ABSTRACT SARS-CoV-2 is the causative agent for the COVID-19 pandemic and there is an
urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin-1 is an …

[HTML][HTML] SARS-CoV-2 ORF3a induces incomplete autophagy via the unfolded protein response

W Su, X Yu, C Zhou - Viruses, 2021 - mdpi.com
In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5
million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits …

Manipulation of autophagy by SARS-CoV-2 proteins

L Koepke, M Hirschenberger, M Hayn, F Kirchhoff… - Autophagy, 2021 - Taylor & Francis
As part of innate immune defenses, macroautophagy/autophagy targets viruses and viral
components for lysosomal degradation and exposes pathogen-associated molecular …

The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis

S Li, H Zhang, W Li, J Zhai, X Li, C Zheng - Autophagy, 2024 - Taylor & Francis
Although alterations in the autophagy-lysosome pathway have been observed in the SARS-
CoV-2 infection and invasion process since the outbreak of the coronavirus disease in 2019 …

[HTML][HTML] ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

D Chen, Q Zheng, L Sun, M Ji, Y Li, H Deng, H Zhang - Developmental cell, 2021 - cell.com
Viral entry and egress are important determinants of virus infectivity and pathogenicity. β-
coronaviruses, including the COVID-19 virus SARS-CoV-2 and mouse hepatitis virus (MHV) …