[HTML][HTML] Mesenchymal stem cell senescence during aging: From mechanisms to rejuvenation strategies

X Jiang, W Li, L Ge, M Lu - Aging and disease, 2023 - ncbi.nlm.nih.gov
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …

[HTML][HTML] Mesenchymal stem cell senescence and rejuvenation: current status and challenges

X Zhou, Y Hong, H Zhang, X Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …

[HTML][HTML] Aging and mesenchymal stem cells: therapeutic opportunities and challenges in the older group

H Chen, O Liu, S Chen, Y Zhou - Gerontology, 2022 - karger.com
With aging, a portion of cells, including mesenchymal stem cells (MSCs), become
senescent, and these senescent cells accumulate and promote various age-related …

The importance of stem cell senescence in regenerative medicine

M Khademi-Shirvan, M Ghorbaninejad… - Cell Biology and …, 2020 - Springer
Mesenchymal stem cells (MSCs) are an interesting tool in regenerative medicine and a
unique cell-based therapy to treat aging-associated diseases. Successful MSC therapy …

[HTML][HTML] Senescence of mesenchymal stem cells

Y Li, Q Wu, Y Wang, L Li, H Bu… - … journal of molecular …, 2017 - spandidos-publications.com
Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases,
due to their immunomodulatory and inflammatory effects. However, the function of MSCs is …

[HTML][HTML] Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Age-related alterations in mesenchymal stem cell function: Understanding mechanisms and seeking opportunities to bypass the cellular aging

M Rasouli, Y Naeimzadeh, N Hashemi… - Current Stem Cell …, 2024 - ingentaconnect.com
Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy
candidates in clinical research and therapy. They not only exert considerable therapeutic …

Senescent mesenchymal stem cells: disease mechanism and treatment strategy

Y Liu, Q Chen - Current molecular biology reports, 2020 - Springer
Abstract Purpose of Review Mesenchymal stem cells (MSCs) have been extensively studied
for therapeutic application in tissue engineering and regenerative medicine. Despite their …

[HTML][HTML] Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches

SS Lee, TT Vũ, AS Weiss, GC Yeo - European Journal of Cell Biology, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the
treatment of degenerative and inflammatory conditions. However, despite accumulating …