The human immunodeficiency virus type 1 (HIV-1) capsid plays crucial roles in HIV-1
replication and thus represents an excellent drug target. We developed a high-throughput …

The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral
genome and is an essential component of the infectious virus. In addition to its multiple roles …

A capsid is the protein shell of a virus, encircling its genetic material. The HIV capsid is
erected from a single protein, known as capsid protein. The capsid of HIV-1 significantly …

Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant
strains continue to emerge, underscoring the need for additional novel mechanism inhibitors …

Recent efforts by both academic and pharmaceutical researchers have focused on the HIV-1
capsid (CA) protein as a new therapeutic target. An interprotomer pocket within the hexamer …

ABSTRACT The HIV-1 capsid (CA) protein plays essential roles in both early and late stages
of virl replication and has emerged as a novel drug target. We report hybrid structure-based …

The human immunodeficiency virus type 1 (HIV-1) capsid protein is an attractive therapeutic
target, owing to its multifunctionality in virus replication and the high fitness cost of amino …

The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs)
that originated with 1 to deliver temsavir (3, BMS-626529) is described. The most beneficial …

The interest in the synthesis of Se-containing compounds is growing with the discovery of
derivatives exhibiting various biological activities. In this manuscript, we have identified a …

The human immunodeficiency virus type 1 (HIV-1) capsid (CA) is an essential viral
component of HIV-1 infection and an attractive therapeutic target for antivirals. Here, we …