Computational framework to understand the clinical stages of COVID‐19 and visualization of time course for various treatment strategies

S Sharma, R Sarkar, K Mitra… - Biotechnology and …, 2023 - Wiley Online Library
Coronavirus disease 2019 is known to be regulated by multiple factors such as delayed
immune response, impaired T cell activation, and elevated levels of proinflammatory …

Data-driven multi-scale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patients

S Wang, M Hao, Z Pan, J Lei, X Zou - PLoS Computational …, 2021 - journals.plos.org
Patients with coronavirus disease 2019 (COVID-19) often exhibit diverse disease
progressions associated with various infectious ability, symptoms, and clinical treatments. To …

Immune‐viral dynamics modeling for SARS‐CoV‐2 drug development

Y Cao, W Gao, L Caro, JA Stone - Clinical and Translational …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) global pandemic is caused by severe acute
respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral infection, which can lead to …

SARS‐CoV‐2 viral dynamic modeling to inform model selection and timing and efficacy of antiviral therapy

S Zhang, AA Agyeman… - CPT …, 2023 - Wiley Online Library
Mathematical models of viral dynamics have been reported to describe adequately the
dynamic changes of severe acute respiratory syndrome‐coronavirus 2 viral load within an …

Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection

R Blanco-Rodriguez, X Du… - Computer methods and …, 2021 - Elsevier
Background: COVID-19 is a global pandemic leading to high death tolls worldwide day by
day. Clinical evidence suggests that COVID-19 patients can be classified as non-severe …

Modeling the viral dynamics of SARS-CoV-2 infection

S Wang, Y Pan, Q Wang, H Miao, AN Brown… - Mathematical …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), an infectious disease caused by the
infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading …

Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients

Z Zhou, D Li, Z Zhao, S Shi, J Wu, J Li… - PLOS Computational …, 2023 - journals.plos.org
Once challenged by the SARS-CoV-2 virus, the human host immune system triggers a
dynamic process against infection. We constructed a mathematical model to describe host …

Data-driven mathematical modeling and dynamical analysis for SARS-CoV-2 coinfection with bacteria

Y Zhou, M Huang, Y Jiang, X Zou - International Journal of …, 2021 - World Scientific
The ongoing coronavirus disease-2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome-coronavirus 2 (SARS-CoV-2) has serious influences on human health …

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

C Voutouri, MR Nikmaneshi… - Proceedings of the …, 2021 - National Acad Sciences
Understanding the underlying mechanisms of COVID-19 progression and the impact of
various pharmaceutical interventions is crucial for the clinical management of the disease …

The good, the bad and the ugly: A mathematical model investigates the differing outcomes among CoVID-19 patients

S Sahoo, S Jhunjhunwala, MK Jolly - Journal of the Indian Institute of …, 2020 - Springer
The disease caused by SARS-CoV-2—CoVID-19—is a global pandemic that has brought
severe changes worldwide. Approximately 80% of the infected patients are largely …