Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Preclinical and clinical studies conducted in the mid-1990s reported strong association and
causality between the T-cell helper (TH) 1 inductor cytokine interleukin (IL)-12 and …

Interleukin (IL)‐12 and IL‐23 are related cytokines that have been implicated in the
pathogenesis of several immune‐mediated disorders. IL‐12 and IL‐23 are heterodimers …

IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential
for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic …

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2–3% of the
population worldwide and has severe effects on patients' physical and psychological well …

Targeting pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) has been an
effective therapeutic approach in patients with a variety of autoimmune diseases, including …

Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse
antibody for treatment of human acute organ rejection. However, the high incidence of …

The discovery of the biological functions of the interleukin-23/-17 axis led to the identification
of IL-23 and IL-17 as important participants in the pathogenesis of several immune-mediated …

The recent advances in the understanding of psoriasis pathogenesis have clarified the
pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the …

Advancements in the immunopathogenesis of psoriasis have identified interleukin (IL)‐23
and IL‐17 as fundamental contributors in the immune pathways of the disease. Leveraging …