Resveratrol: potential application in sepsis

J Li, X Zeng, F Yang, L Wang, X Luo, R Liu… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders
due to infection or infectious factors and is a common complication of patients with clinical …

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

M Vajdi, P Sefidmooye Azar… - Phytotherapy …, 2023 - Wiley Online Library
Sepsis and septic shock are still one of the most important medical challenges. Sepsis is an
extreme and uncontrolled response of the innate immune system to invading pathogenesis …

Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models

J Zhou, D Yang, K Liu, L Hou… - Biomedical …, 2019 - spandidos-publications.com
Sepsis may directly lead to multiple organ failure, which is among the leading causes of
mortality in critically ill patients. According to data released by the Global Sepsis Alliance …

Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study

A Okan, Z Doğanyiğit, S Yilmaz, S Uçar… - Cell Biochemistry …, 2023 - Wiley Online Library
The development and progression of sepsis are multifactorial and influence the
immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the …

[HTML][HTML] Resveratrol alleviates sepsis-induced acute lung injury by suppressing inflammation and apoptosis of alveolar macrophage cells

L Yang, Z Zhang, Y Zhuo, L Cui, C Li, D Li… - American journal of …, 2018 - ncbi.nlm.nih.gov
Sepsis is a major cause of death in intensive care units. The purpose of this study was to
investigate the effect of resveratrol (RSV) on sepsis-induced acute lung injury (ALI). The …

Resveratrol alleviates sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation …

R An, L Zhao, J Xu, C Xi, H Li… - Molecular …, 2016 - spandidos-publications.com
Sepsis is a severe inflammatory response to systemic infection that frequently affects the
myocardium. Previous studies have suggested that resveratrol (RESV) is protective in …

Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation

M Larrosa, M Azorin-Ortuno, MJ Yanez-Gascon… - European journal of …, 2011 - Springer
Purpose The high mortality index due to sepsis and the lack of an effective treatment
requires the search for new compounds that can serve as therapy for this disease …

[HTML][HTML] Resveratrol protects the myocardium in sepsis by activating the phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway …

X Shang, K Lin, R Yu, P Zhu, Y Zhang… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Background Sepsis combined with myocardial injury is an important cause of septic shock
and multiple organ failure. However, the molecular mechanism of sepsis-induced …

Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis

B Wang, GL Bellot, K Iskandar, TW Chong, FY Goh… - Scientific reports, 2020 - nature.com
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to
infection. Due to the heightened immune reactivity and multi-organ pathology, treatment …

Resveratrol reduces renal and lung injury caused by sepsis in rats

M Kolgazi, G Şener, Ş Çetinel, N Gedik… - Journal of Surgical …, 2006 - Elsevier
Resveratrol (3, 5, 4′-trans-trihydroxystilbene), a natural phytoalexin, has various
pharmacological effects, including anti-inflammatory properties via inhibition of oxidation …