Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients
S Elbagir, NEA Mohammed, V Oke, A Larsson… - …, 2024 - academic.oup.com
Abstract Objectives In SLE, anti-dsDNA can co-occur with autoantibodies against other
chromatin components, like histones and nucleosomes. These antibodies induce type-1 …
chromatin components, like histones and nucleosomes. These antibodies induce type-1 …
O30 Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients
S Elbagir, NEA Mohammed, V Oke, A Larsson… - 2024 - lupus.bmj.com
Objective In SLE, anti-dsDNA can co-occur with autoantibodies against other chromatin
components, like histones and nucleosomes. These antibodies induce type-1 Interferon …
components, like histones and nucleosomes. These antibodies induce type-1 Interferon …
Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
S Elbagir, A Sohrabian, AI Elshafie, EM Elagib… - Scientific Reports, 2020 - nature.com
The role of anti-nuclear autoantibody (ANA) specificities in immune complexes (IC)
formation has been studied to a limited extent in SLE, and not at all in African SLE patients …
formation has been studied to a limited extent in SLE, and not at all in African SLE patients …
304 Dysregulated serum cytokines in association with clinical manifestations in patients with systemic lupus erythematosus
L Seridi, S Leonardo, B Scott, RM Gordon, C Shu, K Fei… - 2024 - lupus.bmj.com
Background Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease
affecting multiple organ systems, making clinical trial design challenging. Biomarkers that …
affecting multiple organ systems, making clinical trial design challenging. Biomarkers that …
Network analysis of associations between serum interferon‐α activity, autoantibodies, and clinical features in systemic lupus erythematosus
CE Weckerle, BS Franek, JA Kelly… - Arthritis & …, 2011 - Wiley Online Library
Objective Interferon‐α (IFNα) is a primary pathogenic factor in systemic lupus erythematosus
(SLE), and high IFNα levels may be associated with particular clinical manifestations. The …
(SLE), and high IFNα levels may be associated with particular clinical manifestations. The …
Activation of the interferon pathway is dependent upon autoantibodies in African-American SLE patients, but not in European-American SLE patients
K Ko, Y Koldobskaya, E Rosenzweig… - Frontiers in …, 2013 - frontiersin.org
Background: In systemic lupus erythematosus (SLE), antibodies directed at RNA-binding
proteins (anti-RBP) are associated with high serum type I interferon (IFN), which plays an …
proteins (anti-RBP) are associated with high serum type I interferon (IFN), which plays an …
2104 Lupus autoantibodies associated with cell cycle gene expression in peripheral blood of SLE patients
M Olferiev, D Greenman, J Zhang-Sun, D Fernandez… - 2022 - lupus.bmj.com
Background Gene-expression studies of SLE peripheral blood indicate the expression of
relevant categories of functionally related transcripts. The most pronounced changes have …
relevant categories of functionally related transcripts. The most pronounced changes have …
Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE
EL Hubbard, DS Pisetsky, PE Lipsky - Annals of the rheumatic …, 2022 - ard.bmj.com
Objectives The goals of these studies were to elucidate the inter-relationships of specific anti-
nuclear antibody (ANA), complement, and the interferon gene signature (IGS) in the …
nuclear antibody (ANA), complement, and the interferon gene signature (IGS) in the …
Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus
T Li, SD Prokopec, S Morrison, W Lou, H Reich… - …, 2015 - academic.oup.com
Objective. The aim of this study was to determine whether anti-nucleosome antibodies
function as activity-specific biomarkers in SLE. Methods. Fifty-one patients were recruited …
function as activity-specific biomarkers in SLE. Methods. Fifty-one patients were recruited …
Four anti-dsDNA antibody assays in relation to systemic lupus erythematosus disease specificity and activity
H Enocsson, C Sjöwall, L Wirestam, C Dahle… - The Journal of …, 2015 - jrheum.org
Objective. Analysis of antibodies against dsDNA is an important diagnostic tool for systemic
lupus erythematosus (SLE), and changes in anti-dsDNA antibody levels are also used to …
lupus erythematosus (SLE), and changes in anti-dsDNA antibody levels are also used to …