Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

N Liu, L Zhang, T Tian, J Cheng, B Zhang, S Qiu… - Nature Genetics, 2023 - nature.com
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and
its subfields differ in architecture and function. Genome-wide association studies on …

Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

S Bahrami, K Nordengen, AA Shadrin, O Frei… - Nature …, 2022 - nature.com
Despite its major role in complex human functions across the lifespan, most notably
navigation, learning and memory, much of the genetic architecture of the hippocampal …

Heritability of hippocampal subfield volumes using a twin and non‐twin siblings design

S Patel, MTM Park, GA Devenyi, R Patel… - Human brain …, 2017 - Wiley Online Library
The hippocampus is composed of distinct subfields linked to diverse functions and
disorders. The subfields can be mapped using high‐resolution magnetic resonance images …

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …

B Zhao, T Luo, T Li, Y Li, J Zhang, Y Shan, X Wang… - Nature …, 2019 - nature.com
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

Novel genetic loci associated with hippocampal volume

DP Hibar, HHH Adams, N Jahanshad… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory,
spatial navigation, cognition and stress responsiveness. Structural abnormalities in …

Identification of common variants associated with human hippocampal and intracranial volumes

JL Stein, SE Medland, AA Vasquez, DP Hibar… - Nature …, 2012 - nature.com
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

SJ van Der Lee, MJ Knol, G Chauhan… - Communications …, 2019 - nature.com
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-
wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 …

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

E Horgusluoglu-Moloch, SL Risacher, PK Crane… - Scientific reports, 2019 - nature.com
Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and
contributes to sustaining the hippocampal formation. To investigate whether neurogenesis …

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Nature genetics, 2012 - nature.com
Aging is associated with reductions in hippocampal volume that are accelerated by
Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) …

Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease

DG Ashbrook, RW Williams, L Lu, JL Stein, DP Hibar… - Bmc Genomics, 2014 - Springer
Background Variation in hippocampal volume has been linked to significant differences in
memory, behavior, and cognition among individuals. To identify genetic variants underlying …