The blood–brain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …

The role of the blood brain barrier in neurodegenerative disorders and their treatment

AM Palmer - Journal of Alzheimer's Disease, 2011 - content.iospress.com
Neurodegenerative disorders represent a major medical challenge that is set to increase
substantially in the decades ahead with the massive increase in the number of people in the …

The blood-brain barrier in health and chronic neurodegenerative disorders

BV Zlokovic - Neuron, 2008 - cell.com
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Blood–brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy

BS Desai, AJ Monahan, PM Carvey… - Cell …, 2007 - journals.sagepub.com
The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system.
Though the BBB is thought to be intact during neurodegenerative diseases such as …

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

Basic physiology of the blood-brain barrier in health and disease: a brief overview

M Kaya, B Ahishali - Tissue Barriers, 2021 - Taylor & Francis
The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …

Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier

MA Erickson, K Dohi, WA Banks - Neuroimmunomodulation, 2012 - karger.com
The blood-brain barrier (BBB) is not simply a physical barrier but a regulatory interface
between the central nervous system (CNS) and immune system. The BBB both affects and is …

Functional morphology of the blood–brain barrier in health and disease

S Liebner, RM Dijkhuizen, Y Reiss, KH Plate… - Acta …, 2018 - Springer
The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

HK Alajangi, M Kaur, A Sharma, S Rana, S Thakur… - Molecular Brain, 2022 - Springer
The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …