Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …

Background The dopamine hypothesis, which posits that dysregulation of the dopaminergic
system is etiologic for schizophrenia, is among the most enduring biological theories in …

Risk variants for schizophrenia affect more than 100 genomic loci, yet cell-and tissue-
specific roles underlying disease liability remain poorly characterized. We have generated …

Context Schizophrenia is a common, highly heritable, neurodevelopmental mental illness,
characterized by genetic heterogeneity. Objective To identify abnormalities in the …

Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The
pathophysiology of the illness is not understood, but is thought to have a strong genetic …