Structures of Omicron spike complexes and implications for neutralizing antibody development

H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

Z Zhao, J Zhou, M Tian, M Huang, S Liu, Y Xie… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike's properties, we performed systematic structural analyses on apo …

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

W Du, DL Hurdiss, D Drabek, AZ Mykytyn… - Science …, 2022 - science.org
The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which
displays notable immune escape potential through mutations at key antigenic sites on the …

[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron

Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …

35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope

X Wang, X Chen, J Tan, S Yue, R Zhou, Y Xu, Y Lin… - Cell host & …, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant harbors more than 30 mutations in the spike
protein, leading to immune evasion from many therapeutic neutralizing antibodies. We …

Cryo-EM structure of the SARS-CoV-2 Omicron spike

G Cerutti, Y Guo, L Liu, L Liu, Z Zhang, Y Luo, Y Huang… - Cell reports, 2022 - cell.com
Summary The recently reported B. 1.1. 529 Omicron variant of severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein relative to …

Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …

Structural diversity of the SARS-CoV-2 Omicron spike

SMC Gobeil, R Henderson, V Stalls, K Janowska… - Molecular cell, 2022 - cell.com
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the
previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV …

Omicron Spike protein has a positive electrostatic surface that promotes ACE2 recognition and antibody escape

HH Gan, J Zinno, F Piano, KC Gunsalus - Frontiers in Virology, 2022 - frontiersin.org
High transmissibility is a hallmark of the Omicron variant of SARS-CoV-2. Understanding the
molecular determinants of Omicron's transmissibility will impact development of intervention …