Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies

NJ Dwarshuis, K Parratt, A Santiago-Miranda… - Advanced drug delivery …, 2017 - Elsevier
Therapeutic cells hold tremendous promise in treating currently incurable, chronic diseases
since they perform multiple, integrated, complex functions in vivo compared to traditional …

[HTML][HTML] Industrializing autologous adoptive immunotherapies: manufacturing advances and challenges

RK Iyer, PA Bowles, H Kim, A Dulgar-Tulloch - Frontiers in medicine, 2018 - frontiersin.org
Cell therapy has proven to be a burgeoning field of investigation, evidenced by hundreds of
clinical trials being conducted worldwide across a variety of cell types and indications. Many …

Biomanufacturing for clinically advanced cell therapies

A Aijaz, M Li, D Smith, D Khong, C LeBlon… - Nature biomedical …, 2018 - nature.com
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …

Biomanufacturing of therapeutic cells: state of the art, current challenges, and future perspectives

KH Roh, RM Nerem, K Roy - Annual Review of Chemical and …, 2016 - annualreviews.org
Stem cells and other functionally defined therapeutic cells (eg, T cells) are promising to bring
hope of a permanent cure for diseases and disorders that currently cannot be cured by …

[HTML][HTML] Biological considerations in scaling up therapeutic cell manufacturing

DS Cherian, T Bhuvan, L Meagher… - Frontiers in …, 2020 - frontiersin.org
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …

Addressing the manufacturing challenges of cell-based therapies

M de Almeida Fuzeta, AD de Matos Branco… - Current applications of …, 2020 - Springer
Exciting developments in the cell therapy field over the last decades have led to an
increasing number of clinical trials and the first cell products receiving marketing …

Platforms for manufacturing allogeneic, autologous and iPSC cell therapy products: an industry perspective

E Abraham, BB Ahmadian, K Holderness… - … and manufacturing of …, 2018 - Springer
As cell therapy processes mature from benchtop research protocols to industrial processes
capable of manufacturing market-relevant numbers of doses, new cell manufacturing …

Engineering therapeutic T cells: from synthetic biology to clinical trials

JH Esensten, JA Bluestone… - Annual Review of …, 2017 - annualreviews.org
Engineered T cells are currently in clinical trials to treat patients with cancer, solid organ
transplants, and autoimmune diseases. However, the field is still in its infancy. The design …

Challenges and opportunities in the manufacture and expansion of cells for therapy

JH Maartens, E De-Juan-Pardo… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Laboratory-based ex vivo cell culture methods are largely manual in their
manufacturing processes. This makes it extremely difficult to meet regulatory requirements …

Concise review: guidance in developing commercializable autologous/patient-specific cell therapy manufacturing

S Eaker, M Armant, H Brandwein… - Stem cells …, 2013 - academic.oup.com
Cell therapy is poised to play an enormous role in regenerative medicine. However, little
guidance is being made available to academic and industrial entities in the start-up phase …