A major research focus in the field of cardiovascular medicine is the prospect of using stem
cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent …

Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and
mortality. Heart failure remains a major contributor to this mortality. Despite major …

Cardiovascular disease is still a major cause of ill-health and mortality, heart failure and
arrhythmia being among the causes of sudden cardiac death. There are few drugs available …

Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …

Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …

Stem cells derived from pre-implantation human embryos or from somatic cells by
reprogramming are pluripotent and self-renew indefinitely in culture. Pluripotent stem cells …