Background Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These …
G Campanella, MJ Gunter, S Polidoro… - International journal of …, 2018 - nature.com
Background Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …
MC Benton, A Johnstone, D Eccles, B Harmon… - Genome biology, 2015 - Springer
Background Environmental factors can influence obesity by epigenetic mechanisms. Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …
Objective Analysis of the epigenome—the chemical modifications and packaging of the genome that can influence or indicate its activity—enables molecular insight into cell type …
P Arner, I Sinha, A Thorell, M Rydén… - Clinical …, 2015 - Springer
Background Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics …
Background Obesity is a well-recognized risk factor for insulin resistance and type 2 diabetes (T2D), although the precise mechanisms underlying the relationship remain …
LD Orozco, C Farrell, C Hale, L Rubbi… - Human molecular …, 2018 - academic.oup.com
Most epigenome-wide association studies to date have been conducted in blood. However, metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …
Increased age, BMI and HbA1c levels are risk factors for several non-communicable diseases. However, the impact of these factors on the genome-wide DNA methylation …
Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease, suggesting an important role for adipose tissue in the development of these conditions. The …