The dual role of Natural Killer cells during tumor progression and angiogenesis: Implications for tumor microenvironment-targeted immunotherapies
Immune cell polarization, as a consequence of their cellular plasticity has been described
both for innate and adaptive immunity. This cell polarization is finely tuned in cancers by …
both for innate and adaptive immunity. This cell polarization is finely tuned in cancers by …
Natural killer cells as key players of tumor progression and angiogenesis: old and novel tools to divert their pro-tumor activities into potent anti-tumor effects
Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions
within the tumor microenvironment (TME). Some of these aberrant functions include …
within the tumor microenvironment (TME). Some of these aberrant functions include …
NK cell plasticity in cancer
S Liu, P Dhar, JD Wu - Journal of Clinical Medicine, 2019 - mdpi.com
Natural killer (NK) cells are critical immune components in controlling tumor growth and
dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization …
dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization …
Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent
anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely …
anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely …
Plasticity of NK cells in Cancer
Natural killer (NK) cells are crucial to various facets of human immunity and function through
direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across …
direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across …
Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …
Targeting natural killer cells for tumor immunotherapy
C Zhang, Y Hu, C Shi - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are important innate cytotoxic lymphocytes with a rapid and efficient
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …
Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
New job for NK cells: architects of the tumor microenvironment
NK cells control tumor growth directly through targeted cytotoxic granule release or cytokine
secretion and indirectly by orchestrating anti-tumor immune responses. In this issue of …
secretion and indirectly by orchestrating anti-tumor immune responses. In this issue of …
Natural killer cells in the tumor microenvironment: Enhancing immunotherapy by exploring the communication between nk cells and tumor cells
NA Beelen - 2024 - cris.maastrichtuniversity.nl
Every day, millions of people are confronted with the challenges of cancer, a disease that,
despite advances in treatments, still has a significant mortality rate. This thesis investigates …
despite advances in treatments, still has a significant mortality rate. This thesis investigates …